Clinical Medicine I is the first in a series of four Clinical Medicine courses integrating epidemiology, risk factors (including genetics, as applicable), pathophysiology, signs and symptoms, history and physical findings, laboratory and diagnostic tests, differential diagnosis, therapeutic management, complications, preventative measures, prognosis, patient education and follow-up of emergent and non-emergent disorders encountered in primary care across the lifespan. The course utilizes a systems approach and is delivered through a combination of traditional lectures and problem-based learning (PBL) sessions. The topics are synchronized with and correlative to topics in anatomy, pathophysiology, pharmacology, and physical diagnosis. Organ systems covered in Clinical Medicine I included dermatology, musculoskeletal, autoimmune disorders, ophthalmology, otolaryngology, and infectious disease.